SBA Group for FCPS and MRCP part 1.
Study purpose
A 39-year-old patient has been complaining of headache, weakness, dizziness and pruritus for the
last 2 months. He has also noticed a 12.7 kg weight loss. Gout was diagnosed some 6 months earlier. On examination
he is cyanosed, has hepatosplenomegaly and his blood pressure is 170/100 mmHg.
Which one of the following is the most likely diagnosis?
A. Acute myeloblastic leukaemia
B. Chronic lymphocytic leukaemia
C. Chronic myeloid leukaemia
D. Myeloma
E. Polycythaemia vera
35-year-old woman who has undergone multiple previous blood transfusions develops transfusion
related acute lung injury, shortly after beginning a blood transfusion.
Which of the following is the most likely primary cause?
A. Donor antibodies
B. Donor neutrophils
C. Donor T lymphocytes
D. Host T lymphocytes
E. Host neutrophils
67-year-old woman presents with worsening back pain. She generally weak. An X-ray
of her back shows multiple vertebral collapses . General physical examination apart from pain over the lower
back is unremarkable. Routine blood testing reveals that she is anaemic with a raised viscosity.
Which one of the following is the most likely diagnosis?
A .Bone metastases
B. Chronic myeloblastic leukaemia
C. Multiple myeloma
D. Osteoporosis
E. Osteosarcoma
70-year-old man presents with a 4-month history of weakness and fatigue associated with chronic
nasal bleeding. On direct questioning he also complains of shortness of breath, dizziness and recurrent headaches. On examination he looks
pale and has hepatomegaly. Retinal examination reveals papilloedema with distended retinal vasculature. Hb is 7.0 g/litre.
Given the suspected diagnosis,
what is the next step in obtaining the diagnosis?
A. Liver biopsy
B. Serum protein electrophoresis
C. Abdominal ultrasound
D. Erythrocyte sedimentation rate
E. ECG
A 26-year-old woman who has suffered her third spontaneous abortion is referred by the obstetricians for review. Past history of note includes a deep vein thrombosis that was thought to have been related to a long-haul flight. VDRL testing (used as a syphilis screen) is positive, and IgG anti-cardiolipin antibodies are positive.
What diagnosis fits best with this clinical picture?
A. Antiphospholipid syndrome
B. Protein C deficiency
C. Protein S deficiency
D. SLE
E.Syphilis
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