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*Myocardial Ischemia*

This is the damage or disease in the heart's major blood vessels.

Myocardial ischemia occurs when blood flow to your heart is reduced, preventing the heart muscle from receiving enough oxygen. The reduced blood flow is usually the result of a partial or complete blockage of your heart's arteries (coronary arteries).

Myocardial ischemia, also called cardiac ischemia, reduces the heart muscle's ability to pump blood. A sudden, severe blockage of one of the heart's artery can lead to a heart attack. Myocardial ischemia might also cause serious abnormal heart rhythms

The usual cause is the build-up of plaque. This causes coronary arteries to narrow, limiting blood flow to the heart.

*Symptoms*

Some people who have myocardial ischemia don't have any signs or symptoms (silent ischemia).
When they do occur, the most common is chest pressure or pain, typically on the left side of the body (angina pectoris). Other signs and symptoms — which might be experienced more commonly by women, older people and people with diabetes — include:

i. Neck or jaw pain

ii. Shoulder or arm pain

iii. A fast heartbeat

iv. Shortness of breath when you are physically active

v. Nausea and vomiting

vi. Sweating

vii. Fatigue

*Causes*

Myocardial ischemia occurs when the blood flow through one or more of your coronary arteries is decreased. The low blood flow decreases the amount of oxygen your heart muscle receives.
Myocardial ischemia can develop slowly as arteries become blocked over time. Or it can occur quickly when an artery becomes blocked suddenly.
Conditions that can cause myocardial ischemia include:

i. Coronary artery disease (atherosclerosis).Plaques made up mostly of cholesterol build up on your artery walls and restrict blood flow. Atherosclerosis is the most common cause of myocardial ischemia.

ii. Blood clot. The plaques that develop in atherosclerosis can rupture, causing a blood clot. The clot might block an artery and lead to sudden, severe myocardial ischemia, resulting in a heart attack. Rarely, a blood clot might travel to the coronary artery from elsewhere in the body.

iii. Coronary artery spasm. This temporary tightening of the muscles in the artery wall can briefly decrease or even prevent blood flow to part of the heart muscle. Coronary artery spasm is an uncommon cause of myocardial ischemia.

iv. Chest pain associated with myocardial ischemia can be triggered by:

- Physical exertion

- Emotional stress

- Cold temperatures

- Co***ne use

- Eating a heavy or large meal

- Sexual in*******se

*Risk factors*

Factors that can increase your risk of developing myocardial ischemia include:

i. To***co. Smoking and long-term exposure to secondhand smoke can damage the inside walls of arteries. The damage can allow deposits of cholesterol and other substances to collect and slow blood flow in the coronary arteries. Smoking causes the coronary arteries to spasm and may also increase the risk of blood clots.

ii. Diabetes. Type 1 and type 2 diabetes are linked to an increased risk of myocardial ischemia, heart attack and other heart problems.

iii. High blood pressure. Over time, high blood pressure can accelerate atherosclerosis, resulting in damage to the coronary arteries.

iv. High blood cholesterol level. Cholesterol is a major part of the deposits that can narrow your coronary arteries. A high level of "bad" (low-density lipoprotein, or LDL) cholesterol in your blood may be due to an inherited condition or a diet high in saturated fats and cholesterol.

v. High blood triglyceride level. Triglycerides, another type of blood fat, also may contribute to atherosclerosis.

vi. Obesity. Obesity is associated with diabetes, high blood pressure and high blood cholesterol levels.

vii. Waist circumference. A waist measurement of more than 35 inches (89 centimeters) for women and 40 inches (102 cm) in men increases the risk of high blood pressure, diabetes, and heart disease.

viii. Lack of physical activity. Not getting enough exercise contributes to obesity and is linked to higher cholesterol and triglyceride levels. People who get regular aerobic exercise have better heart health, which is associated with a lower risk of myocardial ischemia and heart attack. Exercise also reduces blood pressure.

*Complications*

Myocardial ischemia can lead to serious complications, including:

i. Heart attack. If a coronary artery becomes completely blocked, the lack of blood and oxygen can lead to a heart attack that destroys part of the heart muscle. The damage can be serious and sometimes fatal.

ii. Irregular heart rhythm (arrhythmia). An abnormal heart rhythm can weaken your heart and may be life-threatening.

iii. Heart failure. Over time, repeated episodes of ischemia may lead to heart failure.

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Feel free to read more on

https://www.mayoclinic.org/diseases-conditions/myocardial-ischemia/symptoms-causes/syc-20375417

https://www.webmd.com/heart-disease/what-is-ischemia

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