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ARGIMIK TABLET

L-arginine
L-arginine is an amino acid that helps the body build protein. It is one of 20 amino acids produced in the body that is needed to make protein. It is considered a semi essential amino acid because although your body generally can make adequate amounts, levels of this amino acid naturally decrease with age and with stress-related conditions. Arginine is sold in many health food stores as a supplement and can also be obtained in some dietary foods. Supplementation is not reserved for men alone, as arginine has multiple well-proven benefits for women, as well.
L-arginine is a supplement that may be helpful for a few specific situations in female and male fertility.
Role in male infertility:
L-arginine found to be helpful in treating low s***m count.
S***m concentration increased after 1-2 months of daily treatment with L-arginine.
It’s thought to work through increased nitric oxide production improving circulation.
Role L-arginine in female infertility:
L-arginine is precursor of nitric oxide which increase blood flow by increasing the dilation of arteries.
Purpose of L-arginine treatment: is to increase the thickness of endometrial linning.
Adequate endometrial thickness is important for supporting a pregnancy.
Thin linning is due to decrease blood flow through the arteries.
Study 1: In study women with thin lining endometrium who took L-arginine, the endometrial lining increased to greater than 8 mm. 1
Research also suggests that L-arginine may be helpful for patients who are poor responders in an IVF cycle. Poor responders are women who respond poorly to ovarian stimulation medication in that they tend to have few eggs to retrieve or IVF cycles are cancelled.
Study 2: In another study patients who were poor responders going through IVF, treatment with L-arginine resulted in a lower frequency of cancelled cycles and an increase in the number of eggs retrieved. 2
Study 3: Later research in patients with tubal infertility showed that L-arginine treatment resulted in fewer good quality embryos and lower pregnancy rates, suggesting that L-arginine may be detrimental for women who are normal responders.
Role of NO and arginase in female s*xual arousal function:
Arginase plays an important role in va**nal engorgement in vitro and in vivo. The availability of l-arginine as a substrate for nitric oxide synthase in NANC nerves and endothelium in ge***al tissues may be reduced by increased arginase activity in response to disease or injury. Competition for the substrate l-arginine may be pronounced if l-arginine is present within a compartmentalized pool shared by these competing enzymes. Intracellular arginine availability may be further reduced in aging, diabetes, or atherosclerosis. If this were the case, it would be anticipated that alterations in arginase in various disease states would cause decreased NO production in response to s*xual stimulation. These pathological changes would lead to insufficient perfusion or engorgement of ge***al tissues and dysfunctional s*xual arousal responses in both men and women. As evidenced by the upregulation of arginase in specific disease states, its differential distribution in the va**na, and its modulation by s*x steroid hormones, this enzyme may also participate in numerous other physiological and pathophysiological processes such as tissue growth, fibrosis, and immune function.
L-arginine reliably increases libido:
Supplemention with L-arginine can expand both s*xual excitement and desire. This helps you reach or**sm by amplifying both ge***al blood flow and smooth-muscle relaxation.
Once it gets in your body, L-arginine enhances s*xual responsiveness by increasing the nitric oxide in your blood, which relaxes and expands your blood vessels. This lifts libido by:
Intensifying sensation
Increasing the flow of oxygenated blood
Stimulating the entire va**nal, and even the cl****al, area.
All of these physical effects of L-arginine mean that s*x can quickly become more pleasurable. Plus, your desire is noticeably increased.
Effects of L‐arginine on uterine spontaneous contractions
Human myometrial strips from non‐pregnant women developed spontaneous phasic contractile activity.
The addition of increasing concentrations of L‐arginine to contractile myometrial strips induced a concentration‐dependent partial inhibition of the phasic contractile uterine activity. The spontaneous contraction was reduced by 65% in the presence of L‐arginine.
Role of L-arginine in PCOS:
Nitric Oxide (NO) plays pivotal roles in many physiological functions which are compromised in PCOS. Recent study reveals that lowered T-regulatory cells in PCOS, and Treg generation is known to be regulated by NO levels.
PCOS women showed reduced plasma NOx (nitrate + nitrite) due to reduced transcript levels of iNOS/NOS2 and eNOS/NOS3 in peripheral blood, high ADMA synthesis and reduced arginine bioavailability.
H₂O₂ concentration in PCOS women also found to be reduced. The reduction can be attributed to increase in catalase levels as a consequence of the body’s effort to alleviate the oxidative burden in the system.
Other effects of L-arginine
L-arginine also stimulates the release of growth hormone, insulin and other substances in the body.
It is a physiological precursor of diverse biological compounds such as nitric oxide, polyamines, proline, glutamate, creatine, agmatine and urea.
As a booster of immunity it stimulate the thymus and promote lymphocyte production.

1.Exercise and weight loss benefits:
Arginine is needed for the synthesis of creatine, which is important for muscle contraction and helps to supply energy to all cells in the body. It is used to improve athletic performance, stimulate the release of growth hormone and reduce fatigue during workouts. Arginine can aid in the reduction of body fat by improving the body's nitrogen balance, allowing increased metabolism and conversion of protein into muscle mass. A study in the "Journal of Applied Physiology" showed that supplementation with arginine enhanced high-intensity exercise tolerance, allowing participants to extend their workout duration and exercise efficiency.
2. L-arginine and insulin sensitivity:
Diabetes is associated with reduced plasma levels of arginine and elevated levels of the NOS inhibitor ADMA. Evidence suggests that arginine supplementation may be an effective way to improve endothelial function in individuals with diabetes mellitus (DM). As well, low dose IV arginine has been shown to improve insulin sensitivity in obese, type 2 DM and healthy subjects. Arginine may also counteract lipid peroxidation and thereby reduce microangiopathic long-term complications of DM.
L-arginine regulates insulin release by NO-dependent and NO-independent pathway.
3. L-arginine and wound healing:
Wound healing involves platelets, inflammatory cells, fibroblasts and epithelial cells. All of these cell types are capable of producing NO either constitutively or in response to inflammatory cytokines. NO produced by both iNOS and eNOS plays many important roles in wound healing, from the inflammatory phase through to scar remodeling. NO has cytostatic, chemotactic and vasodilatory effects during early wound repair, regulates proliferation and differentiation of several cell types, modulates collagen deposition and angiogenesis, and affects wound contraction
The healing effect of l-arginine is also extended to cover burn injuries. Burn injuries significantly increase arginine oxidation and fluctuations in arginine reserves. L-arginine improves collagen deposition and wound strength.This effect may be due to the increase in production of ornithine by the action of arginase enzyme, a precursor of l-proline during collagen synthesis. L-Arginine might improve wound immune cell function by decreasing the inflammatory response at the wound site.
4. L-arginine and CNS functions:
L-arginine supplementation play role in formation of memory in CNS.
Experiments suggest that NO is involved in memory function. NO is released from a postsynaptic source to act presynaptically on one or more neurons after specific receptor stimulation. This leads to a further increase in the release of glutamate and, as a result, to a stable increase in synaptic transmission, a phenomenon known as long-term potentiation.
5. Arginine and muscular activity:
L-Arginine plays role on muscular activity. Treatment shows enhanced maximal oxygen consumption as well as decreased plasma lactate concentration. Athletes can take arginine for three main reasons:
(1) its role in the secretion of endogenous growth hormone.
(2) its involvement in the synthesis of creatine.
(3) its role in augmenting nitric oxide.
6. Vascular effects of dietary L-arginine supplementation:
The vascular endothelium plays an important role in vascular physiology. Endothelial production of nitric oxide as a key element in many of the processes associated with the development of atherosclerosis. L-arginine is the substrate for the enzyme nitric oxide synthase (NOS), which is responsible for the endothelial production of nitric oxide.
Long-term oral l-arginine supplementation for 6 months in humans improves coronary small-vessel endothelial function in association with a significant improvement in symptoms and a decrease in plasma endothelin concentrations.
L-arginine shows therapeutic role in patients with chest pain and coronary endothelial dysfunction.
7. Effect of L-arginine in immune system:
As a booster of immunity, it stimulates the thymus and promote lymphocyte production.

ENDOMETRIOSIS AND FIBROID

LETRAST 2.5MG

Letrozole is an aromatase inhibitor that is used for many different purposes in women’s health including treatment of infertility, endometriosis, and uterine fibroids. Letrozole is a non-hormonal medication called an aromatase inhibitor. Letrozole works by shrinking down fibroid size to improve fibroid-related symptoms. Although letrozole is used to treat some gynecologic conditions, it is approved by the FDA for a different purpose: to treat postmenopausal women with hormone sensitive breast cancer

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