AntiAgingResearch.TV

Common Amino Acid May Affect How Long Men Live A large new study suggests that higher levels of a common amino acid called tyrosine may be linked to a shorter lifespan in men. The research, published recently in the journal Aging-US, examined whether blood levels of two amino acids, phenylalanine and tyrosine, were...

Unlocking Longevity: Polyphenols' Role in Profound Reductions in Mortality Risk () Imagine reducing your risk of early death by over a third just by what you eat. Unveil the power of polyphenols in this insightful exploration The connection between diet, lifestyle, and longevity has been a subject of extensive research.

Excerpt from NIH
Metformin: A Potential Candidate for Targeting Aging Mechanisms
Aging is a universal phenomenon in all biological organisms, defined by the loss of reproductive capacity and a progressive decline in fitness. In humans, aging is further associated with an increased incidence of disease conditions. The current aging population has become a primary public burden of the 21st century. Therefore, to delay the aging process and maintain fitness in the aging population, the discovery of novel anti-aging drugs remains an urgent need. In recent years, metformin, a widely used hypoglycemic drug, has attracted growing attention in the field of anti-aging research. Reportedly, numerous studies have indicated that metformin regulates aging-related pathways, possibly delaying the aging process by modulating these pathways. The elucidation of these anti-aging effects may provide insights into the age-retarding potential of metformin. The present review focuses on the predominant molecular mechanisms associated with aging, as well as the anti-aging effects of metformin.

Keywords: metformin, aging, Insulin-Like Growth Factor I, oxidative stress, proteostasis
With advancements in health care and medical technologies, the human life span has been consistently growing. However, the downside of this health prosperity is an increasingly aging. According to the World Health Organization (WHO), between 2015 and 2050, the proportion of the population aged over 60 years will increase from 12% to 22% worldwide [1], translating into a population of 2 billion. In addition to reduced fitness, aging is a major risk factor for numerous age-related diseases, including diabetes [2], cancer [3], neurodegenerative diseases [4], and cardiovascular disorders [5].

Notably, the rate of human aging is influenced by genetic and environmental factors expressed through changes in various cellular signaling pathways and metabolic processes, including oxidative stress [6], telomere attrition [7], epigenetic alterations [8], proteostasis, autophagy and mitochondrial functions [9]. Furthermore, it remains controversial whether aging is a programmed process. However, recent studies investigating several metabolism altering drugs, including metformin [10], rapamycin [11], resveratrol [12], spermidine [13], curcumin [14] and astaxanthin [15], have suggested that while the aging process, cannot be rewired, it could be delayed. Importantly, these drugs have served as molecular tools, allowing us to examine pathways and mechanisms impacting the aging process. In this review, we will focus on metformin, a first-line drug used for the treatment of type 2 diabetes, and assess its anti-aging effects, as well as underlying mechanisms.

Metformin: A Potential Candidate for Targeting Aging Mechanisms Aging is a universal phenomenon in all biological organisms, defined by the loss of reproductive capacity and a progressive decline in fitness. In humans, aging is further associated with an increased incidence of disease conditions. The current aging ...

Saudi Arabia plans to spend $1 billion a year discovering treatments to slow aging The oil kingdom fears that its population is aging at an accelerated rate and hopes to test drugs to reverse the problem. First up might be the diabetes drug metformin.

Is Aging a Disease or a Natural Process? Mystery, stigma and dreams of immortality fuel a debate that just won’t die

Five Ways Exercise Actually Makes You Look YOUNGER - www.thenutritionwatchdog.com By: Cat Ebeling, co-author of the best-sellers: The Fat Burning Kitchen, The Top 101 Foods that Fig

1. zzzZZZzzz - Lack of sleep is the culprit behind aging and many other health related issues…and best of all…It’s free.

2. Fasting - According to Harvard aging-researcher Dr. David Sinclair, intermittent fasting is a very effective way of slowing the aging process, because in the fasted state, the body has a chance to repair cells.

3. Sauna - Regularly hitting the sauna is an incredibly cost effective anti-aging strategy. Especially considering that a regular schedule of saunas (three times a week) has shown to reduce all-cause mortality by 42%!

4. Cold showers - Just as heat has many positive anit-aging properties, so has getting cold. Short, but intense exposure to cold temperature increases blood flow and releases a cocktail of hormones, that essentially keep your cells young and vibrant.

5. Resistance training - Get your swell on! Growing muscle and getting stronger will protect you against many forms of cancer, prevent strokes and increase your quality of life. Muscle mass is correlated to longevity and health (up to a point).

6. Cardio or endurance training - Going for a run or doing burpess in your living room is free. Plus, a healthy cardio-vascular system is shown to prevent all kinds of cancer forms and even mental health issues.

7. Regulating stress levels - Meditation. Breathing techniques. Mental reframes. All free. All extremely potent anti-aging and life-quality enhancers. Why is this NOT taught in schools?

8. Eating more vegetables and less sugar - You’ve got to spend money on food anyway…Why not buy more veggies instead of candy bars? BONUS TIP: Find it hard to cook and prepare healthy meals? Get a blender and make yourself smoothies (blend the veggies together with tasty fruits).

9. Eating less meat and animal protein - Again, according to age-researchers Dr David Sinclair and Dr Valter Longo, excessive animal protein has shown to upregulate a hormone called IGF-1 (Insuling like Growth Factor). IGF-1 is not bad per se, as it also helps grow and maintain muscle. The problem is, that high levels of IGF-1 might be responsible for cancer cell growth.
Staying hydrated - Keeps your skin supple.

10. Not being broke - Although money has no direct correlation to do with the physical aspects of aging, money definately plays a role in psychological well-being. No, money by itself doesn’t make you happy. But as I can tell you first hand, a lack of money causes extreme worry. Anxiety and other mental health impairments caused by worry, have a measurable and researched impact on health markers. So save your money and invest it intelligently, so that you don’t have to spend all of it, to get your health back in your 50’s and 60’s.

11. Eating the right kind of fats - Eating the wrong type of fat, increases your risk of cardio vascular diseases, dementia and cancer. Reduce Omega-6 fatty acids intake and increase your consumption of Omega-3 fatty acids.

Dog People Live Longer. But Why? Hanging out with dogs might be good for your health. A researcher reviews the science and discusses the very real link between dog ownership and reduced risk of dying from cardiovascular disease.

What are the best ways to increase chances of living to be a hundred years old? Answer (1 of 128): How can I live to 100? (Thanks for the “ask to answer.”) Tips on How to Live to One Thousand Years of Age 1. If you are over 30 years of age and are not taking cycloastragenol on a daily basis, start taking it; if you are taking cycloastragenol, continue taking as much as yo.....

Lifting Weights As You Age Cuts Your Risk Of Early Death By 46% Discover the science of how strength training keeps you young

David Sinclair Is Extending Human Lifespan | Rich Roll Podcast David Sinclair PhD is a biologist and Professor of Genetics at Harvard Medical School, co-director of the Paul F. Glenn Center for the Biological Mechanisms ...