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Wow, that’s a lot. Is that why people can’t get their COVID-19 test results for several days? We use this same technique to test for all kinds of other viruses, from influenza to Zika, said Dr. Mary Jo Trepka, an infectious disease epidemiologist at Florida International University.

Well, no. This process is not particularly special or time-consuming and involves techniques used all the time in genetic research. PCR, in particular, is so crucial to the entire field that the guy who invented it won a Nobel Prize back in 1993.

Compare that to South Korea, where people can get their results in about a day. There, the government had been stockpiling the necessary chemicals for years after COVID-19’s cousin MERS briefly hit that country in 2015. That helped the country move quickly to approve and decentralize testing as soon as COVID-19 arrived.
So, wait. Is there no difference between South Korea’s test and ours, then?

There is a difference, but that doesn’t have much to do with why ours takes so much longer, Smith said. The differences are really just about which primers are being used. Researchers choose which chunks of a virus’s genetic code to use as a primer with an eye to making sure those primers are a) unique to the specific virus they’re looking for and b) likely to get preserved in any random bit of viral RNA scraped off the back of somebody’s nasal cavity. If the primer isn’t unique enough, you can get false positives. If the sequence your primer is looking for doesn’t make it from nose to test tube, then you’ll get false negatives.

There’s not really anything wrong with the primers the CDC test uses, Smith told me. Even when the CDC test was malfunctioning, that was about an inconsistent reagent, not the unique primers. South Korea is faster than us because it can conduct the tests in more places, and could right from the start. Plus, it has more supplies to do the tests with.
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